General Information

  • ID:  hor005189
  • Uniprot ID:  P47216
  • Protein name:  Galanin
  • Gene name:  gal
  • Organism:  Pelophylax ridibundus (Marsh frog) (Rana ridibunda)
  • Family:  Galanin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Pelophylax (genus), Ranidae (family), Ranoidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  GWTLNSAGYLLGPHAIDNHRSFNDKHGLA
  • Length:  29(1-29)
  • Propeptide:  GWTLNSAGYLLGPHAIDNHRSFNDKHGLA
  • Signal peptide:  NA
  • Modification:  T29 Alanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion;elevates the concentration of CAMP in the frog anterior pituitary
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: 9.3*10(-8)M
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P47216-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P47216-F1.pdbhor005189_AF2.pdbhor005189_ESM.pdb

Physical Information

Mass: 366211 Formula: C141H209N43O41
Absent amino acids: CEMQV Common amino acids: GL
pI: 7.8 Basic residues: 5
Polar residues: 11 Hydrophobic residues: 10
Hydrophobicity: -52.76 Boman Index: -4222
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 77.59
Instability Index: 1413.79 Extinction Coefficient cystines: 6990
Absorbance 280nm: 249.64

Literature

  • PubMed ID:  7540547
  • Title:  Frog vasoactive intestinal polypeptide and galanin: primary structures and effects on pituitary adenylate cyclase.